Chronic Childhood Stress Leaves Lasting Impact on Brain. An interesting article…

By  Associate News Editor
Reviewed by John M. Grohol, Psy.D. on June 29, 2014

child-covering-eyes-with-hands-blond-white-big-SSExtreme stress experienced during childhood, such as poverty, neglect, and physical abuse, might alter the parts of the brain responsible for learning, memory, and the processing of stress and emotion.

These changes may be linked to negative effects on behavior, health, employment, and even the choice of romantic partners later in life, according to researchers from the University of Wisconsin-Madison.

“We haven’t really understood why things that happen when you’re two, three, four years old stay with you and have a lasting impact,” said Dr. Seth Pollak, co-leader of the study and UW-Madison professor of psychology.

“Yet,” noted Pollak, “early life stress has been linked to depression,anxiety, heart disease, cancer, and a lack of educational and employment success.”

“Given how costly these early stressful experiences are for society … unless we understand what part of the brain is affected, we won’t be able to tailor something to do about it,” said Pollak, also director of the UW Waisman Center’s Child Emotion Research Laboratory.

The study involved 128 children, approximately age 12, who had experienced either physical abuse, neglect early in life, or came from low socioeconomic status.

The children and their caregivers underwent in-depth interviews, reporting behavioral problems and their cumulative life stress. The researchers also took images of the children’s brains, focusing on the hippocampus and amygdala, parts of the brain involved in emotion and stress processing. These images were compared to similar children from middle-class households who had not been maltreated.

The researchers outlined each child’s hippocampus and amygdala by hand and calculated their volumes. Both brain structures are very small, especially in children, and the researchers believed that automated software measurements might be prone to error.

The findings showed that children who experienced any of the three types of early life stress had smaller amygdalas than children who had not. Children who lived in poverty and children who had been physically abused also had smaller hippocampal volumes.

Putting the same images through automated software showed no effects. Behavioral problems and increased cumulative life stress were linked to smaller hippocampus and amygdala volumes.

“For me, it’s an important reminder that as a society we need to attend to the types of experiences children are having,” Pollak said. “We are shaping the people these individuals will become.”

But the findings, say the researchers, are only markers for neurobiological change — a display of the robustness of the human brain, and not a crystal ball to be used to see the future.

“Just because it’s in the brain doesn’t mean it’s destiny,” said study author and UW Ph.D. graduate Jamie Hanson.

The study is published in the journal Biological Psychiatry.

Article courtesy and originally from:

Source: University of Wisconsin-Madison

Image courtesy of Shutterstock


Take the ‘Weird’ test and see where you fit in!

Bizarre and Peculiar Abstract Human Art courtesy of via Google Images.
Bizarre and Peculiar Abstract Human Art courtesy of via Google Images.

I love the realistic fantasy, which tricks the eye and mind at first gaze… #odd

Bizarre art image courtesy of via Google Images.
Bizarre art image courtesy of via Google Images.

The infamous ‘illuminate’ tree! Apparently, ‘illuminate tree’ or ‘IT’ as he’s called in the forest, is being held captive by a crazy antique tree watcher! The tree watcher from antiquity, is obviously forcing ‘IT’ to painfully gaze upon a true schizophrenic with paranoid delusions. With a piece of art so bizarre, why wouldn’t my explanation be bizzare as well?

Bizarre Rabbit Art Print by Ruben Ireland. image courtesy of via Google Images.
Bizarre Rabbit Art Print by Ruben Ireland. image courtesy of via Google Images.

Did you notice the fella is bald and has one helluva moustache? That wasn’t what I observed first! I had to look at it for a few seconds… #Bizarre

Bizarre Tree Art. Image courtesy of via Google Images.
Bizarre Tree Art. Image courtesy of via Google Images.

In all my years, growing up in the country, building tree forts, and playing in the woods daily, I never was lucky enough to see a tree like this! I mean, I built some mean wooden fortresses… I even had booby traps set up around my camoflouged perimeter… I would have given that all up as a boy to see a tree like this! I know, I’m a typical male…can’t help that! #wood

Dark Art Skull Manipulation by Fabio Carito. Image courtesy of via Google Images.
Dark Art Skull Manipulation by Fabio Carito. Image courtesy of via Google Images.

The Walking Dead? Beauty and youth versus mortality and time? The lifeless gaze of a living corpse? Either answer or answers could be both the question and the answer. That’s the beauty of all art… it’s open to individual interpretation! #thewalkingdead

Bizarre Street Art. Image from via Google Images.
Bizarre Street Art. Image from via Google Images.

Although, definitely not a traditional oil on canvas, I feel the canvas is absolutely appropriate that this artist used. A wonderfully macabre peice of art! #macabre

Joseph-Barbaccia-obesity-bizarre-strange-art-human-body image courtesy of via Google Images.
Joseph-Barbaccia-obesity-bizarre-strange-art-human-body image courtesy of via Google Images.

Words… perhaps aren’t necessary for this piece. Bizarre and a little gross, but it does force the viewer to figure out what’s happening in this picture. I did the picture. I glean my own definition, my own understanding… what do you think of this artwork? #obesity

If you found 3 or more of the above pictures, somehow cool, then you are officially in the most intelligent group, the ‘Weird’ group! 

If you found 2 or less of the above pictures, somewhat, not cool, then you are officially in the Republican Party! Just kidding, just kidding… but no, you are definitely less intelligent than the weirdos!

I hope you enjoyed the odd art and simple writing. I enjoyed writing and researching! I’m a nerd and a weirdo!

Thanks again and come back! Like my blog please!

Emery Myers

Narcissistic personality disorder…What is it? Do you know somebody…read more…click link…

Do you know someone that most people can’t stand due to their huge ego? Does the person drive you crazy? If so, this article is for you! We enjoy your company...Keep coming back!

Narcissistic personality disorder

How do you spot a narcissist image from via Google Images How do you spot a narcissist? Image from via Google Images

Have you heard of the word narcissist before? What does the word mean to you? For many years, I thought it was simply, a person that loved one’s self more than anyone else…a person that was an ‘ego-maniac’. Simple…much too simple, as I have found out over the years.

Narcissist’s naturally have over-inflated perceptions of themselves’. Narcissistic personality disorder is characterized by dramatic, emotional behavior, which is in the same category as antisocial and borderline personality disorders.

Why-We-Love-Narcissists image courtesy of via Google Images Why-We-Love-Narcissists image courtesy of via Google Images

Narcissistic personality disorder symptoms may include:

  • Believing that you’re better than others
  • Fantasizing about power, success and attractiveness
  • Exaggerating your achievements or talents
  • Expecting constant praise and admiration
  • Believing that you’re special and acting accordingly
  • Failing to recognize other people’s emotions and feelings
  • Expecting others to go along with your ideas…

View original post 337 more words

Narcissistic personality disorder…What is it? Do you know somebody…read more…click link…

Narcissistic personality disorder

How do you spot a narcissist image from via Google Images
How do you spot a narcissist? Image from via Google Images

Have you heard of the word narcissist before? What does the word mean to you? For many years, I thought it was simply, a person that loved one’s self more than anyone else…a person that was an ‘ego-maniac’. Simple…much too simple, as I have found out over the years.

Narcissist’s naturally have over-inflated perceptions of themselves’. Narcissistic personality disorder is characterized by dramatic, emotional behavior, which is in the same category as antisocial and borderline personality disorders.

Why-We-Love-Narcissists image courtesy of via Google Images
Why-We-Love-Narcissists image courtesy of via Google Images

Narcissistic personality disorder symptoms may include:

  • Believing that you’re better than others
  • Fantasizing about power, success and attractiveness
  • Exaggerating your achievements or talents
  • Expecting constant praise and admiration
  • Believing that you’re special and acting accordingly
  • Failing to recognize other people’s emotions and feelings
  • Expecting others to go along with your ideas and plans
  • Taking advantage of others
  • Expressing disdain for those you feel are inferior
  • Being jealous of others
  • Believing that others are jealous of you
  • Trouble keeping healthy relationships
  • Setting unrealistic goals
  • Being easily hurt and rejected
  • Having a fragile self-esteem
  • Appearing as tough-minded or unemotional

Although some features of narcissistic personality disorder may seem like having confidence or strong self-esteem, it’s not the same. Narcissistic personality disorder crosses the border of healthy confidence and self-esteem into thinking so highly of yourself that you put yourself on a pedestal. In contrast, people who have healthy confidence and self-esteem don’t value themselves more than they value others.

Celebrities are more likely to be narcissistic. Image courtesy of via Google Images
Celebrities are more likely to be narcissistic according to the most recent psychological science. Excessive “Selfies” are also an indicator of narcissism.                                    Image courtesy of via Google Images

When you have narcissistic personality disorder, you may come across as conceited, boastful or pretentious. You often monopolize conversations. You may belittle or look down on people you perceive as inferior. You may have a sense of entitlement. And when you don’t receive the special treatment to which you feel entitled, you may become very impatient or angry. You may insist on having “the best” of everything — the best car, athletic club, medical care or social circles, for instance.

But underneath all this behavior often lies a fragile self-esteem. You have trouble handling anything that may be perceived as criticism. You may have a sense of secret shame and humiliation. And in order to make yourself feel better, you may react with rage or contempt and efforts to belittle the other person to make yourself appear better.

This information from the Mayo Clinic Staff, is intended for educational/entertainment. If you feel you have any mental issues, please contact your doctor. This article is simply explaining what a narcissist really is.

Thank you for reading.

~Cannablogna Staff~

For original source information, please click HERE.

You Gotta See THIS!

The Hulk like you’ve never seen him!


China’s Real Estate Downturn Spells Trouble for Global Economy

What Does This Soul Graffiti Do for You?

Bizarre Street Art. Image from via Google Images.
Bizarre Street Art. Image from via Google Images. #Bizarre

Hideous and malevolent… yet oddly, beautiful.

Greek Graffiti 2. Image from via Google Images.
Greek Graffiti 2. Image from via Google Images. 

Scary surrealism in this postapocalyptic street graffiti scene…

Social Vandalism Street Artworks. Image from via Google Images
Social Vandalism Street Artworks. Image from via Google Images. #Bizarre

Even if you don’t “get it”, you “feel it”!

Street Art. Image from via Google Images
Street Art. Image from via Google Images. 
I hope you enjoyed this little art exhibit!
Emery Myers

~Would~ by Alice in Chains! If you don’t know this band then shame on YOU!

Perhaps one of the top, original bands of all time, but plagued with tragedy and hopelessness. The music paints the emotional stage for the band!

Alice in Chains: Original information source HERE.

Alice in Chains is an American rock band formed in SeattleWashington, in 1987 by guitarist and songwriter Jerry Cantrell and original lead vocalist Layne Staley. The initial lineup was rounded out by drummer Sean Kinney, and bassist Mike Starr (who was replaced in 1993 by Mike Inez).

Although widely associated with grunge music, the band’s sound incorporates heavy metal and acoustic elements. Since its formation, Alice in Chains has released five studio albums, three EPs, two live albums, four compilations, and two DVDs. The band is known for its distinct vocal style which often included the harmonized vocals of Staley and Cantrell.

Alice in Chains rose to international fame as part of the grunge movement of the early 1990s, along with other Seattle bands such asNirvanaPearl Jam, and Soundgarden. The band was one of the most successful music acts of the 1990s, selling over 20 million albums worldwide,[1] and over 14 million in the US alone.[2] In 1992, the band released their album Dirt, which was critically acclaimed and has been certified quadruple platinum. The band also achieved two No. 1 Billboard 200 releases, 14 top ten songs on theMainstream Rock Tracks chart and eight Grammy Award nominations.

Although never officially disbanding, Alice in Chains was plagued by extended inactivity from 1996 onwards due to Staley’s substance abuse, which resulted in his death in 2002. The band reunited in 2005 with new lead vocalist William DuVall, and released their fourth studio album, Black Gives Way to Blue, in 2009. The album was a success, being certified gold by the RIAA in 2010. Alice in Chains released their fifth studio album, The Devil Put Dinosaurs Here, on May 28, 2013. They are currently on tour for this album.[3]

Common Sense is Genius in It’s Working Clothes.

Common Sense is Genius in It’s Working Clothes.

written by Emery Myers, May 23rd, 2014

Common Sense is Genius image courtesy of whatantseesdotwordpressdotcom
Common Sense is Genius… image courtesy of

What happened to common sense in America? Did it ever truly exist? It’s hard to answer this question without relying on what other humans recorded throughout human history. Some recorded history is accurate… I am sure of that, but much of recorded history is, dare I say, conjecture, hear-say, mistakes and recorded decades after the fact. Impossible to prove much of ancient history…unless we have tangible evidence and the science scholars involved. If you don’t accept science, carbon-14 dating, or evolutionary biology, physics and the other sciences, then you probably aren’t going to agree with this article.

Common Sense image courtesy of universityofcommonsensedotcom
Common Sense image courtesy of

I am a college graduate. My wife is a college graduate. College education did not teach either of us what common sense is. We had common sense before college. Education does not gift a person with common sense. I have worked with many people in my life and I’ll take common sense over education level any time of the day! I have met people with 10-plus years of higher education and absolutely no common sense… Some of the most brilliant minds I have ever known have a very limited educational background but are the epitome of common sense and intelligent decision-making!

Common Sense Bring it Back courtesy of wwwdotsalescoachdocom
Common Sense, Bring it Back courtesy of

Seriously… Bring it back now! Americans are either too afraid to speak up and use their first amendment rights, or lack good, old commonsense! The majority in Cannablogna’s polling indicates the latter… commonsense is endangered! It is quickly becoming non-existent in our America. This is what the leaders of huge corporations and our political system count on. The powers that be want us to be scared, confused and fearful of everything. It keeps us “controlled”. It keeps us in our social caste. It forces us to be consumers! It Keeps us… the 99 PERCENT!

common sense just because you can courtesy of wwwdotsodaheaddotcom
Common sense, just because you can… courtesy of

I have quite literally, been killed, hundreds of times in my work career. The majority of accidents were caused by idiots as pictured above! We all have seen them, tried to communicate with them, and tried to pull their weight. The people lacking common sense… their numbers are growing rapidly! The CDC should have released a report years ago! How many people die in workplace accidents or are seriously injured, due to someone else’s lack of common sense? We know all too well that it was probably an idiot lacking commonsense.

That Video, courtesy of, pretty much wraps up any further need for explanation.

Your friend in commonsense,

Emery Myers, contributing author for, and

Please sign this petition if you believe in commonsense!
Please click and sign our petition to decriminalize a medicinal plant, cannabis and allow patients safe access to a medicine that has been used for more than 5000 years by humans.




Cannabis Scientifically Proven to Treat Alzheimer’s Disease, Cancer, Epilepsy, Chronic Pain and Parkinson’s Disease Among Other Serious Medical Conditions.

Cannabis Proven to Treat Alzheimer’s Disease, Cancer and Parkinson’s Disease Among Other Serious Medical Conditions.

Neurosurgeon and CNN medical correspondent Dr. Sanjay Gupta was against Cannabis in a 2009 TIME magazine article. Now, he is one of the biggest advocates of the natural medicine. Image courtesy of Google Images.

This isn’t a new development. Ancient man used cannabis for pain relief, medicinal qualities and religious/spiritual rituals, among many other uses both medicinal and industrial.

Cannabis oil has been found in the mummified remains of Egyptians, ancient Chinese writings and cave drawings. For more information and timeline of Cannabis use in Human History, please click the green link:

History of Cannabis Use in Humans.

There are thousands of patient testimonials, physician testimonials and scientific articles on the health effects of Cannabis. Of course, every medicine has side effects and I would be remiss to suggest that this plant works for everyone or has no potential for abuse. Humans abuse everything from laxatives to alcohol to prescription drugs. I would also be irresponsible to suggest using Cannabis to anyone. Different states have different laws, and while 21 states have enacted medical marijuana laws, the U.S. Government still deems Cannabis a dangerous drug with NO medicinal use. The Federal Government classifies Cannabis as a Schedule 1 drug, which puts it in the same class as Heroin.

Image courtesy of
Image courtesy of This is a real picture of real results. Visit the website for more information.

This is simply an article presenting a history of the use of Cannabis in Humans throughout the centuries and also several videos of actual physician and patient testimonials. This article is intended to provide evidence and education on the anti-cancer properties of this complex plant known as Cannabis.

The following information was taken directly from

Laboratory/Animal/Preclinical Studies

Anti-tumor Effects
Appetite Stimulation

Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely byCannabis species (e.g., Cannabis sativa L.) .[1,2] These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.

Anti-tumor Effects:

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors(polyps and adenomas) in other organs (mammary glanduterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[58]

Cannabinoids may cause anti-tumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[912] Two reviews summarize the molecular mechanisms of action of cannabinoids as anti-tumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their non-transformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in gliomacells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]

The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[16] Both agents reduced the viability of HCC cells in vitro and demonstrated anti-tumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma [17] and breast cancer.[18]

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancercell lines, inducing apoptosis in a concentration-dependent manner while having little effect on non-tumorigenic, mammary cells.[19]

CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[20] In the experimental system, azoxymethane increased  premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[21]

Another investigation into the anti-tumor effects of CBD examined the role of intercellular adhesion molecule-1 (ICAM-1).[12] ICAM-1 expression has been reported to be negatively correlated with cancermetastasis. In lung cancer cell lines, CBD upregulated ICAM-1, leading to decreased cancer cell invasiveness.

In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[22] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[23,24]

In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatoryeffects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[25] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[2629]

CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[30] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.

Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[31] Moreover, CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.[32]


Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists. The CB1 receptor is found in both the central nervous system (CNS) and in peripheral nerve terminals. Similar toopioid receptors, increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.[33] CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.[34,35]

Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[3638] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[39]

Please click and sign our petition to decriminalize a medicinal plant, cannabis and allow patients safe access to a medicine that has been used for more than 5000 years by humans. THE SCIENCE IS IN. THIS PLANT CURES AND PREVENTS CANCER. THIS PLANT TREATS MANY SERIOUS MEDICAL CONDITIONS. IT’S THE 21ST CENTURY. TIME FOR COMMON SENSE AND DRUG LAW REFORM.


  1. Adams IB, Martin BR: Cannabis: pharmacology and toxicology in animals and humans. Addiction 91 (11): 1585-614, 1996.  [PUBMED Abstract]
  2. Grotenhermen F, Russo E, eds.: Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential. Binghamton, NY: The Haworth Press, 2002.
  3.  National Toxicology Program .: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 446 (): 1-317, 1996.  [PUBMED Abstract]
  4. Bifulco M, Laezza C, Pisanti S, et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148 (2): 123-35, 2006.  [PUBMED Abstract]
  5. Sánchez C, de Ceballos ML, Gomez del Pulgar T, et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61 (15): 5784-9, 2001. [PUBMED Abstract]
  6. McKallip RJ, Lombard C, Fisher M, et al.: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 (2): 627-34, 2002.  [PUBMED Abstract]
  7. Casanova ML, Blázquez C, Martínez-Palacio J, et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111 (1): 43-50, 2003. [PUBMED Abstract]
  8. Blázquez C, González-Feria L, Alvarez L, et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 (16): 5617-23, 2004.  [PUBMED Abstract]
  9. Guzmán M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (10): 745-55, 2003. [PUBMED Abstract]
  10. Blázquez C, Casanova ML, Planas A, et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17 (3): 529-31, 2003.  [PUBMED Abstract]
  11. Vaccani A, Massi P, Colombo A, et al.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144 (8): 1032-6, 2005.  [PUBMED Abstract]
  12. Ramer R, Bublitz K, Freimuth N, et al.: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26 (4): 1535-48, 2012.  [PUBMED Abstract]
  13. Velasco G, Sánchez C, Guzmán M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012.  [PUBMED Abstract]
  14. Cridge BJ, Rosengren RJ: Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Manag Res 5: 301-13, 2013.  [PUBMED Abstract]
  15. Torres S, Lorente M, Rodríguez-Fornés F, et al.: A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10 (1): 90-103, 2011.  [PUBMED Abstract]
  16. Vara D, Salazar M, Olea-Herrero N, et al.: Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ 18 (7): 1099-111, 2011.  [PUBMED Abstract]
  17. Preet A, Qamri Z, Nasser MW, et al.: Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4 (1): 65-75, 2011.  [PUBMED Abstract]
  18. Nasser MW, Qamri Z, Deol YS, et al.: Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS One 6 (9): e23901, 2011.  [PUBMED Abstract]
  19. Shrivastava A, Kuzontkoski PM, Groopman JE, et al.: Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10 (7): 1161-72, 2011.  [PUBMED Abstract]
  20. Aviello G, Romano B, Borrelli F, et al.: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J Mol Med (Berl) 90 (8): 925-34, 2012.  [PUBMED Abstract]
  21. Romano B, Borrelli F, Pagano E, et al.: Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. Phytomedicine 21 (5): 631-9, 2014. [PUBMED Abstract]
  22. Preet A, Ganju RK, Groopman JE: Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 27 (3): 339-46, 2008.  [PUBMED Abstract]
  23. Zhu LX, Sharma S, Stolina M, et al.: Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol 165 (1): 373-80, 2000. [PUBMED Abstract]
  24. McKallip RJ, Nagarkatti M, Nagarkatti PS: Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 174 (6): 3281-9, 2005.  [PUBMED Abstract]
  25. Massa F, Marsicano G, Hermann H, et al.: The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest 113 (8): 1202-9, 2004.  [PUBMED Abstract]
  26. Patsos HA, Hicks DJ, Greenhough A, et al.: Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans 33 (Pt 4): 712-4, 2005.  [PUBMED Abstract]
  27. Liu WM, Fowler DW, Dalgleish AG: Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids. Curr Clin Pharmacol 5 (4): 281-7, 2010. [PUBMED Abstract]
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Article written by Emery Myers RN, DON-CLTC

This article is not a substitute for medical advice. Any decisions medically, should be discussed with your primary care physician. If you live in a state where Cannabis is illegal, then these treatment options are not available for any person legally.

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